- Chemical Name Brefeldin A
- CAS No. 20350-15-6
- Contact Us Inquiry
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1.What is the Brefeldin A ?
Brefeldin A (20350-15-6) is a specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. Induces apoptosis. Brefeldin A activates sphingomyelin metabolism. Cell permeable.
Brefeldin A (BFA) is a natural fungal metabolite which has been used extensively to study intracellular transport by vesicles or endosomes. Early studies demonstrated that BFA reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum. BFA directly and reversibly inhibits Sec7 domain-containing guanine-exchange factors which are necessary for ADP-ribosylation factor activation associated with vesicular transport (IC50 = ~10 μM). BFA is used to study endosomal trafficking and function in cells of plants as well as those of fungi, invertebrates, and vertebrates.
2.What is the CAS number for Brefeldin A ?
The CAS number of Brefeldin A is 20350-15-6.
More information of Brefeldin A 20350-15-6 are:
|
CAS?Number |
20350-15-6 |
|
Density |
1.108 g/cm3 |
|
Melting Point |
200-205 °C |
|
Boiling Point |
492.7 °C at 760 mmHg |
|
Flash Point |
180.8 °C |
|
Vapor Pressure |
0mmHg at 25°C |
|
Refractive Index |
1.513 |
|
HS CODE |
29411090 |
|
PSA |
66.76000 |
|
LogP |
1.96240 |
|
Pka |
12.92±0.60(Predicted) |
3.What is the molecular formula of Brefeldin A ?
The chemical formula of?Brefeldin A is C16H24O4 which containing 16 Carbon atoms,24 Hydrogen atoms and 4 Oxygen atoms,and the molecular weight, and the molecular weight of Brefeldin A is 280.364
4.What is Brefeldin A(20350-15-6)used for?
Brefeldin A (20350-15-6) is a specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. Induces apoptosis. Brefeldin A activates sphingomyelin metabolism. Cell permeable.
InChI:InChI=1/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4-,8-7-/t11-,12-,13-,14+,15+/m0/s1
Relevant articles related to Brefeldin A:
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Article |
Source |
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A trans-vinylogous ester anion equivalent and its application to the synthesis of (+)-brefeldin A |
Suh, Young-Ger,Seo, Seung-Yong,Jung, Jae-Kyung,Park, Ok-Hui,Jeon, Ra-Ok , p. 1691 - 1694 (2001) |
|
Synthesis and cytotoxic evaluation of acylated brefeldin a derivatives as potential anticancer agents |
He, Bingyong,Wang, Yajun,Zheng, Yuguo,Chen, Wei,Zhu, Qing , p. 307 - 316 (2013) |
5.Buy Good Quality Brefeldin A 20350-15-6 with a minimum purity of 99%
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