- Chemical Name1-Methyl-3-pyrrolidinol
- CAS No. 13220-33-2
- Contact UsInquiry
Factory Sells Best Quality 1-Methyl-3-pyrrolidinol 13220-33-2 with stock
- Molecular Formula:C5H11NO
- Molecular Weight:101.148
- Appearance/Colour:Colorless or light yellow liquid
- Vapor Pressure:0.132mmHg at 25°C
- Refractive Index:n20/D 1.464(lit.)
- Boiling Point:192.2 °C at 760 mmHg
- PKA:14.95±0.20(Predicted)
- Flash Point:70.6 °C
- PSA：23.47000
- Density:1.045 g/cm3
- LogP:-0.37930
1-Methyl-3-pyrrolidinol(Cas 13220-33-2) Usage
InChI:InChI=1/C5H11NO/c1-6-3-2-5(7)4-6/h5,7H,2-4H2,1H3/p+1/t5-/m0/s1
13220-33-2 Relevant articles
Preparation method of 1-methyl-3-pyrrolidinol
-
Paragraph 0146-0148, (2021/09/01)
The invention relates to the technical f...
Preparation method of N-substituent-3-hydroxytetrahydropyrrole
-
Paragraph 0022; 0023; 0024; 0025; 0026; 0027, (2017/08/29)
The invention discloses a preparation me...
Carry over of impurities: A detailed exemplification for glycopyrrolate (NVA237)
Allmendinger, Thomas,Bixel, Dominique,Clarke, Adrian,Di Geronimo, Laura,Fredy, Jean-Wilfried,Manz, Marco,Gavioli, Elena,Wicky, Regine,Schneider, Martin,Stauffert, Fabien J.,Tibi, Markus,Valentekovic, Darko
supporting information, p. 1754 - 1769 (2013/01/15)
The original synthesis of glycopyrrolate...
Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors
Bekkali, Younes,Thomson, David S.,Betageri, Raj,Emmanuel, Michel J.,Hao, Ming-Hong,Hickey, Eugene,Liu, Weimin,Patel, Usha,Ward, Yancey D.,Young, Erick R.R.,Nelson, Richard,Kukulka, Alison,Brown, Maryanne L.,Crane, Kathy,White, Della,Freeman, Dorothy M.,Labadia, Mark E.,Wildeson, Jessi,Spero, Denice M.
, p. 2465 - 2469 (2008/03/11)
The synthesis and in vitro activities of...
13220-33-2 Process route
-
-
2419-74-1,847375-52-4
1,4-dichlorobutan-2-ol
-
-
74-89-5
methylamine
-
-
13220-33-2,99445-21-3
1-methyl-3-pyrrolidinol
| Conditions | Yield |
|---|---|
|
In
water;
at 10 - 120 ℃;
for 10h;
under 7500.75 Torr;
Temperature;
Pressure;
Autoclave;
Sealed tube;
|
64.8% |
|
1,4-dichlorobutan-2-ol; methylamine;
In
water;
at 10 - 15 ℃;
for 10h;
Autoclave;
methylamine;
With
sodium hydroxide;
at 50 ℃;
for 1h;
|
-
-
131237-81-5,104612-35-3,19948-27-7
3-hydroxy-N-methylsuccinimide
-
-
13220-33-2,99445-21-3
1-methyl-3-pyrrolidinol
| Conditions | Yield |
|---|---|
|
With
sodium tetrahydroborate; Trimethyl borate; dimethyl sulfate;
In
tetrahydrofuran;
at 0 - 30 ℃;
for 2h;
Reagent/catalyst;
Inert atmosphere;
|
43.2 g |
13220-33-2 Upstream products
-
14891-10-2
ethyl-3-oxo-1-pyrrolidinecarboxylate
-
19398-47-1
1,4-dibromo-2-butanol
-
74-89-5
methylamine
-
554-15-4
1-methyl-2,5-dihydro-pyrrole
13220-33-2 Downstream products
-
117450-21-2
2-<(1-methyl-3-pyrrolidinyl)oxy>-5-phenyl-3-pyridinecarboxylic acid sodium salt
-
270580-23-9
methyl N-methyl-3-pyrrolidinyl phenyl(cyclopentyl)malonate
-
434332-38-4
1-methyl-3-pyrrolidinyl phenylacetate
-
873912-87-9
N-methyl-3-pyrrolidinyl (-)-cyclopentylmandelate