Home > Pharmaceutical

  • Chemical Name Edoxaban
  • CAS No. 912273-65-5
  • Contact Us Inquiry

Quality Manufacturer Supply High Purity 99% Edoxaban 912273-65-5 with Reasonable Price

  • Molecular Formula: C7H8O3S*C24H30ClN7O4S
  • Molecular Weight: 720.27
  • PSA： 164.87000 
  • Density: 1.43 
  • LogP: 2.08230 

912273-65-5 Relevant articles

PROCESS FOR PREPARATION OF EDOXABAN

-

, (2021/01/23)

The present invention relates to process...

Preparation method of edoxaban tosylate and isomers thereof

-

, (2021/02/06)

The invention discloses a preparation me...

Method for the Preparation of Diamine Derivative

-

Paragraph 0164-0280; 0289-0338, (2021/03/23)

The present invention relates to high yi...

Method for preparing edoxaban from trichloroacetophenone onium salt derivatives

-

, (2020/07/21)

The invention provides a method for prep...

912273-65-5 Process route

(1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxy-N,N-dimethylcyclohexanecarboxamide
929693-30-1

(1S,3R,4R)-3-[(tert-butoxycarbonyl)amino]-4-hydroxy-N,N-dimethylcyclohexanecarboxamide

[14C]-Edoxaban tosylate
480449-71-6,912273-65-5

[14C]-Edoxaban tosylate

Conditions
Conditions Yield
Multi-step reaction with 6 steps
1.1: triethylamine / 4-methyl-2-pentanone (MIBK) / 1 h / 20 °C
2.1: sodium azide; N-dodecylpyridinium chloride / toluene; water / 47 h / 60 - 63 °C / Dean-Stark
3.1: ammonium formate / palladium-carbon / methanol / 1 h / 40 °C
3.2: 17 h / 20 °C
4.1: triethylamine / acetonitrile / 6 h / 60 °C
5.1: methanesulfonic acid / acetonitrile / 2 h / 20 °C
5.2: 16 h / 20 °C / Cooling with ice
6.1: dichloromethane; ethanol
With sodium azide; methanesulfonic acid; ammonium formate; N-dodecylpyridinium chloride; triethylamine; palladium-carbon; In methanol; ethanol; dichloromethane; 4-methyl-2-pentanone (MIBK); water; toluene; acetonitrile;
Multi-step reaction with 7 steps
1.1: triethylamine / 4-methyl-2-pentanone (MIBK) / 1 h / 20 °C
2.1: sodium azide; N-dodecylpyridinium chloride / ethyl acetate; N,N-dimethylacetamide (DMAC) / 72 h / 20 - 60 °C
3.1: ammonium formate / palladium-carbon / acetonitrile; methanol / 1 h / 40 °C
4.1: acetonitrile; water / 17 h / 20 °C
5.1: triethylamine / acetonitrile / 6 h / 60 °C
6.1: methanesulfonic acid / acetonitrile / 2 h / 20 °C
6.2: 16 h / 20 °C / Cooling with ice
7.1: dichloromethane; ethanol / 20 °C
With sodium azide; methanesulfonic acid; ammonium formate; N-dodecylpyridinium chloride; triethylamine; palladium-carbon; In methanol; N,N-dimethylacetamide (DMAC); ethanol; dichloromethane; 4-methyl-2-pentanone (MIBK); water; ethyl acetate; acetonitrile;
Multi-step reaction with 7 steps
1.1: triethylamine / 4-methyl-2-pentanone (MIBK) / 1 h / 20 °C
2.1: sodium azide; N-dodecylpyridinium chloride / ethyl acetate; N,N-dimethylacetamide (DMAC) / 72 h / 20 - 60 °C
3.1: ammonium formate / palladium-carbon / acetonitrile; methanol / 1 h / 40 °C
4.1: acetonitrile; water / 17 h / 20 °C
5.1: triethylamine / acetonitrile / 7 h / 60 - 75 °C
6.1: methanesulfonic acid / acetonitrile / 2 h / 20 °C
6.2: 16 h / 20 °C / Cooling with ice
7.1: dichloromethane; ethanol / 20 °C
With sodium azide; methanesulfonic acid; ammonium formate; N-dodecylpyridinium chloride; triethylamine; palladium-carbon; In methanol; N,N-dimethylacetamide (DMAC); ethanol; dichloromethane; 4-methyl-2-pentanone (MIBK); water; ethyl acetate; acetonitrile;
Multi-step reaction with 7 steps
1.1: triethylamine / 1 h / 15 - 30 °C
2.1: dodecylpyridinium chloride; sodium azide / toluene / 72 h / 60 °C
3.1: palladium-carbon; ammonium formate / methanol / 1 h / 40 °C
4.1: acetonitrile; water / 17 h / 20 °C
5.1: triethylamine / acetonitrile / 22 h / 20 - 60 °C
6.1: methanesulfonic acid / acetonitrile / 2 h / 20 °C
6.2: 16 h / 20 °C
7.1: water; ethanol / 1 h / 70 °C
With sodium azide; methanesulfonic acid; palladium-carbon; ammonium formate; dodecylpyridinium chloride; triethylamine; In methanol; ethanol; water; toluene; acetonitrile;
edoxaban
480449-70-5

edoxaban

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

N<sup>1</sup>-(5-chloropyridin-2-yl)-N<sup>2</sup>-((1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-{[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl)ethanediamide p-toluenesulfonate
912273-65-5

N1 -(5-chloropyridin-2-yl)-N2 -((1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-{[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl)ethanediamide p-toluenesulfonate

Conditions
Conditions Yield
In ethanol; water; at 20 - 60 ℃; for 24h;
86%

912273-65-5 Upstream products

  • 480449-70-5
    480449-70-5

    edoxaban

  • 104-15-4
    104-15-4

    toluene-4-sulfonic acid

  • 480452-36-6
    480452-36-6

    carbamic acid, N-[(1R,2S,5S)-2-[[2-[(5-chloro-2-pyridinyl)amino]-2-oxoacetyl]amino]-5-[(dimethylamino)carbonyl]cyclohexyl]-1,1-dimethylethyl ester

  • 480450-69-9
    480450-69-9

    tert-butyl N-[(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate

Related products

  • Product Name CAS No.