- Chemical Name COMBRETASTATIN A-4
- CAS No. 117048-59-6
- Contact Us Inquiry
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What is the COMBRETASTATIN A-4 ?
COMBRETASTATIN A-4 is crystalline powder, while it's Molecular Formula is C18 H20 O5 . Combretastatin A4 has been used: as an anti-tubulin agent to determine the effects of isocitrate dehydrogenases (IDH1 and IDH2) proteins in G2/M phase to evaluate the anti-proliferative and pro-apoptotic properties of biphenyl CA4 derivatives in both 2D and 3D cancerous and non-cancerous cell models as a microtubule inhibitor to study its effects on motility of Ascaris suum L3 larvae
What is the CAS number for COMBRETASTATIN A-4 ?
The CAS number of COMBRETASTATIN A-4 is 117048-59-6.
More information of COMBRETASTATIN A-4 117048-59-6 are:
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Synonyms |
Phenol,2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]-, (Z)-;CRC 87-09;Combretastatin 4;NSC 613729;NSC 817373; |
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CAS?Number |
117048-59-6 |
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Molecular Formula |
C18 H20 O5 |
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Molecular Weight |
316.354 |
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Density |
1.184 g/cm3 |
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Melting Point |
84.5-85.5 °C |
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Boiling Point |
490.269 °C at 760 mmHg |
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Flash Point |
250.306 °C |
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HS CODE |
29095000 |
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PSA |
57.15000 |
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LogP |
3.59700 |
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Pka |
9.65±0.10(Predicted) |
What is COMBRETASTATIN A-4 (117048-59-6) used for?
Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively. CA4 inhibits tubulin polymerization with an IC50 value of 2.2 μM.
InChI:InChI=1/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5+
Articles related to COMBRETASTATIN A-4:
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Article |
Source |
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Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model |
Shen, Cheng-Huang,Shee, Jia-Jen,Wu, Jin-Yi,Lin, Yi-Wen,Wu, Jiann-Der,Liu, Yi-Wen , p. 2008 - 2027 (2010) |
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Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action |
Huang, Xiaochao,Huang, Rizhen,Gou, Shaohua,Wang, Zhimei,Liao, Zhixin,Wang, Hengshan , p. 2132 - 2148 (2016) |
How to get the best price on COMBRETASTATIN A-4?
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