- Chemical Name CAPSAZEPINE
- CAS No. 138977-28-3
- Contact Us Inquiry
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1.What is the CAPSAZEPINE ?
Capsazepine is shown to inhibit the development of mechanical hyperalgesia induced by intraplanar capsaicin injection. Capsazepine is described to block Resiniferatoxin (sc-24015)- and Capsaicin-induced contractions of guinea pig treacheal smooth muscle. Studies investigating the function of the VR1 (TRPV1 receptor) have employed Capsazepine as a tool for perturbing systemic neuronal response to Capsaicin.
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17608-10-5
2-(4-chlorophenyl)ethyl isothiocyanate
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7,8-dihydroxy-2,3,4,5-tetrahydro-2-benzazepine hydrobromide
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138977-28-3
capsazepine
| Conditions | Yield |
|---|---|
|
With
triethylamine;
In
tetrahydrofuran;
for 18h;
|
79%
|
|
With
triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
|
70%
|
|
With
triethylamine;
In
DMF (N,N-dimethyl-formamide);
for 65h;
|
-
![7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine](/upload/2026/6/e6c50c46c6544630b5f70852fba22d28_5acd24af-576e-4d3c-bead-6574d48e6af8.png)
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95469-38-8
7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepine
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138977-28-3
capsazepine
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1: 58 percent / 48percent aq. HBr / 24 h / Heating
2: 79 percent / Et3
N / tetrahydrofuran / 18 h
With
hydrogen bromide; triethylamine;
In
tetrahydrofuran;
|
2.What is the CAS number for CAPSAZEPINE ?
The CAS number of CAPSAZEPINE is 138977-28-3.
More information of CAPSAZEPINE 138977-28-3 are:
|
CAS?Number |
138977-28-3 |
|
Density |
1.351 g/cm3 |
|
Melting Point |
155-157 °C |
|
Boiling Point |
581.133 °C at 760 mmHg |
|
Flash Point |
305.259 °C |
|
Vapor Pressure |
4.19E-14mmHg at 25°C |
|
Refractive Index |
1.671 |
|
PSA |
87.82000 |
|
LogP |
3.94540 |
|
Pka |
9.73±0.20(Predicted) |
3.What are another words for CAPSAZEPINE ?
Synonyms?for?CAPSAZEPINE 138977-28-3:CAPSAZEPINE;N-[2-(CHLOROPHENYL)ETHYL]-1,3,4,5-TETRAHYDRO-7,8-DIHYDROXY-2H-2-BENZAZEPINE-2-CARBOTHIOAMIDE;N-[2-(4-CHLOROPHENYL)ETHYL]-1,3,4,5-TETRAHYDRO-7,8-DIHYDROXY-2H-2-BENZAZEPINE-2-CARBOTHIOAMIDE;CAPSAZEPINE SYNTHETIC ANALOG OF C;2-[[2-(4-Chlorophenyl)ethylamino]thiocarbonyl]-2,3,4,5-tetrahydro-1H-2-benzazepine-7,8-diol;Capsazepine,98%
4.What is the molecular formula of CAPSAZEPINE?
The chemical formula of ?CAPSAZEPINE is?C19 H21 ClN2 O2 S which containing 19 Carbon atoms,21 Hydrogen atoms,1 Chlorine atoms,2 Nitrogen atoms,2 Oxygen atoms and 1 Sulfur atoms,and the molecular weight of??CAPSAZEPINE?is 376.907.
5.What is CAPSAZEPINE (138977-28-3) used for?
Transient receptor potential vanilloid type 1 (TRPV1) is a member of the transient receptor potential (TRP) family that is activated or sensitized by a variety of endogenous stimuli as a result of tissue injury and inflammation. TRPV1 is upregulated during inflammation and plays a role in the perception of pain. Capsazepine is a competitive antagonist of transient receptor potential vanilloid type 1 (TRPV1) which blocks the capsaicin-induced uptake of Ca2+ in neonatal rat dorsal root ganglia with an IC50 of 0.42 μM and Chinese hamster ovary cells with an IC50 of 17 nM. It does not block acid- or heat-induced activation of TRPV1 and may block receptors other than TRPV1.
InChI:InChI=1/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
Relevant articles related to CAPSAZEPINE:
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Article |
Source |
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SAR studies of capsazepinoid bronchodilators. Part 1: The importance of the catechol moiety and aspects of the B-ring structure |
Dalence-Guzman, Maria F.,Berglund, Magnus,Skogvall, Staffan,Sterner, Olov , p. 2499 - 2512 (2008/09/21) |
6.Buy CAPSAZEPINE with the best price .
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